General Information
Zepbound (tirzepatide) is an FDA-approved medicine used for weight loss and weight management to help you lose weight and keep weight off, and it is also used for obstructive sleep apnea (OSA) with obesity. Zepbound works by reducing your appetite and making you feel full more quickly and for a longer period of time, so you eat less and lose weight. Zepbound for weight loss and sleep apnea is given as a once-weekly injection under the skin and should be used together with diet and exercise.
How does Zepbound work?
Zepbound is a GIP and GLP-1 receptor agonist.
Zepbound’s mechanism of action is by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors.
Zepbound works like two natural hormones in our bodies, called GIP and GLP-1, which help control appetite, blood sugar levels, and digestion. When Zepbound binds to GIP and GLP-1 receptors, it slows the rate food passes through your body, making you feel full longer, and the pancreas releases more insulin, lowering the amount of sugar your liver makes. This helps weight loss and may also lower blood sugar levels.
Who is eligible for Zepbound?
The FDA approved Zepbound for adults ages 18 and older who are dealing with obesity or are overweight and have additional weight-related health challenges.
Doctors use BMI to classify who is obese or overweight. Low Wang said BMI is far from a perfect measure of a person’s health. Some people have a higher BMI and are perfectly healthy. These drugs may not be right for them.
Meanwhile, other people who have high BMIs are dealing with serious related health problems like high blood pressure, diabetes, and elevated risk of heart attack, stroke, heart failure or liver disease.
To qualify for Zepbound, patients need to have a BMI of 30 and higher – which means they’re dealing with obesity – or a BMI of 27 or greater – the marker for being overweight – while they are also dealing with at least one other weight-related health condition. These conditions include high blood pressure, high cholesterol or Type 2 diabetes.
Who should not take Zepbound?
People who are pregnant should never take these medications. They need to be eating well and gaining weight to support their pregnancies.
FDA officials say people who have a personal or family history of medullary thyroid cancer should not use Zepbound along with patients with Multiple Endocrine Neoplasia syndrome type 2.
In addition, Zepbound has not been studied in patients with a history of pancreas inflammation (pancreatitis) or severe gastrointestinal disease (including severe gastroparesis, a condition that affects normal movement of the muscles in the stomach), according to the FDA.
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